Clinical Data

The use of our magnetically controlled capsule endoscopy system has been dynamically tested for efficacy in a variety of clinical settings. A number of recent publications, including on our NaviCam® Stomach System and NaviCam® SB Systems can be found below. Please contact us for a complete list of published papers in addition to numerous accepted abstracts.

NaviCAM® SB

Gastroenterologist-Level Identification of Small-Bowel Diseases and Normal Variants by Capsule Endoscopy Using a Deep-Learning Model

Ding Z., Shi H., et al.
Gastroenterology 2019;157:1044–1054


Conclusions:
We validated the ability of a CNN based algorithm to identify abnormalities in SB-CE images. The CNN-based auxiliary model identified abnormalities with higher levels of sensitivity and significantly shorter reading times than conventional analysis by gastroenterologists. This algorithm provides an important tool to help gastroenterologists analyze SB-CE images more efficiently and more accurately.

Magnetic Steering of Capsule Endoscopy Improves Small Bowel Capsule Endoscopy Completion Rate

Luo YY., Pan J., Chen YZ. et al.
Dig Dis Sci 64, 1908-1915 (2019)


Conclusions:
Magnetic steering of capsule endoscopy improves small bowel CECR by reducing GTT, adding further support to MCE as a practical tool for noninvasive examination of both the stomach and small bowel.

AI-assisted capsule endoscopy reading in suspected small bowel bleeding: a multicentre prospective study

Cristiano Spada*, Stefania Piccirelli*, Cesare Hassan, Clarissa Ferrari, Ervin Toth, Begoña González-Suárez, Martin Keuchel, Marc McAlindon, Ádám Finta, András Rosztóczy, Xavier Dray, Daniele Salvi, Maria Elena Riccioni, Robert Benamouzig, Amit Chattree, Adam Humphries, Jean-Christophe Saurin, Edward J Despott, Alberto Murino, Gabriele Wurm Johansson, Antonio Giordano, Peter Baltes, Reena Sidhu, Milan Szalai, Krisztina Helle, Artur Nemeth, Tanja Nowak, Rong Lin, Guido Costamagna

Magnetically Controlled Capsule Endoscopy (MCCE)

Magnetically controlled capsule for assessment of the gastric mucosa in symptomatic patients: a prospective, single-arm, single-center, comparative study

Andrew C. Meltzer, MD, MS,1 Anita Kumar, MD,1 Samuel J. Kallus, MD,1 Samuel A. Schueler, MD,1 Nikhil Mattu, BS,1 Yan Ma, PhD,2 Yijie He, MS,1 David E. Fleischer, MD,3 David R. Cave, MD, PhD4


Conclusions:
In the first pilot study of MCCE in the United States, a high rate of visualization of all regions of the gastric mucosa was achieved. In addition, high satisfaction and no adverse events were recorded. Future studies will focus on higher-risk cohorts to confirm the accuracy of detection of benign, premalignant, and malignant gastric lesions.

Screening for gastric cancer with magnetically controlled capsule gastroscopy in asymptomatic individuals.

Zhao AJ., Qian YY., Sun H., et al.
Gastrointestinal Endoscopy 2018; 88:466-474


Conclusions:
MCCG can detect cancer and benign lesions and is safe and clinically feasible in a large population. Studies of its role in a screening program should be considered.

Accuracy of Magnetically Controlled Capsule Endoscopy, Compared with Conventional Gastroscopy in Detection of Gastric Diseases

Liao Z., Hou X., et al
Clin Gastroenterol Hepatol 2016; 14:1266–73


Conclusions:
Magnetically Controlled Capsule Endoscopy detects focal lesions in the upper and lower stomach with comparable accuracy with conventional gastroscopy. MCE is preferred by almost all patients, compared with gastroscopy, and can be used to screen gastric diseases without sedation.

Clinical Efficiency and Safety of Magnetic‑Controlled Capsule Endoscopy for Gastric Diseases in Aging Patients: Our Preliminary Experience

Zhang S., Sun T., Xie Y., et al.
Dig Dis Sci 64,2911-2922 (2019)


Conclusions:
Our preliminary data support that MCE offers considerable benefit and is general safe for the elderly. We hope such data promote greater awareness of innovative attempts for the specific elderly, and expect multi-center, large-scale trials with randomized controlled design bring optimized strategies for better gastric visibility, efficacy and lower potential risk.

Magnetic Steering of Capsule Endoscopy Improves Small Bowel Capsule Endoscopy Completion Rate

Luo YY., Pan J., Chen YZ., et al.
Dig Dis Sci 64, 1908-1915 (2019)


Conclusions:
Magnetic steering of capsule endoscopy improves small bowel CECR by reducing GTT, adding further support to MCE as a practical tool for noninvasive examination of both the stomach and small bowel.

Magnetic-controlled capsule endoscopy vs. gastroscopy for gastric diseases: a two-center self-controlled comparative trial

Zou, WB., Hou, XH., Xin, L., et al.
Endoscopy 2015; 47(06): 525-528


Conclusions:
MCE showed a diagnostic accuracy similar to that of standard gastroscopy. These results suggest that MCE is a promising alternative to gastroscopy for noninvasive screening of gastric diseases.

Preliminary study of magnetically controlled capsule gastroscopy for diagnosing superficial gastric neoplasia.

Qian Y-Y., et al.
Digestive and Liver Disease, Volume 50, Issue 10, P1041-1046, October 01, 2018


Conclusions:
With good gastric preparation and careful examination of stomach, MCCG is able to detect superficial gastric neoplasms.

Standardized examination procedure of magnetically controlled capsule endoscopy

Jiang, X., Pan, J., et al.
VIDEOGIE, 2019 May 30;4(6) 239-243

NaviCam® UGI
Detachable String Magnetically Controlled Capsule Endoscopy

Better view by detachable string magnetically controlled capsule endoscopy for esophageal observation: a retrospective comparative study

Song, T. Bai, L. Zhang, X.-L. Xiang, X.-P. Xie, X.-H. Hou
Diseases of the Esophagus, Volume 33, Issue 4, April 2020, doz104


Conclusions:
Detachable string MCE has better performance for observing the different esophageal segments, especially the middle and lower esophagus and Z-line. Further measures are needed to improve viewing of the upper and lower esophagus and Z-line by detachable string MCE. Detachable string MCE allowed the detection of more esophageal focal lesions and is a promising alternative tool for screening for esophageal diseases.

Detachable string magnetically controlled capsule endoscopy for detecting high-risk varices in compensated advanced chronic liver disease (CHESS1801)

Wang S, Huang Y., et al.
A prospective multicenter study


Conclusions:
In conclusion, DS-MCCE was an accurate, safe alternative to EGD for detecting HRV in patients with cACLD. In addition, DS-MCCE was better tolerated and thus may be indicated for those unwilling or unable to undergo EGD screening for HRV.

Detachable string magnetically controlled capsule endoscopy for complete observation of the upper gastrointestinal tract

Xiu H., Lu Y., Lui, X., et al.
Eur J Gastroenterol Hepatol. 2020, Sep 17.doi:10.1097


Conclusions:
DS-MCCE is feasible and well tolerated in the diagnosis of gastroesophageal diseases. For people who cannot stand conventional EGD or with contraindication of EGD, DS-MCCE may be an excellent alternative screening modality.

Detachable string magnetically controlled capsule endoscopy for complete viewing of the esophagus and stomach

Chen ZY., Pan J., Luo YY.; et al.
Endoscopy 2019; 51(04): 360-364


Conclusions:
DS-MCE was a feasible, safe, and well-tolerated method for viewing the esophagus and proceeding with gastric examination after string detachment.

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